Mw. P. (Patrycja) M. Jurecka: “Transferrin polymorphism of common carp. Link with disease resistance”

  News
  Newsroom
  Dossiers
  Archive
  Calendar
  2012
  2011
  2010
  2009
  2008
  2007
  2006
  2005
  2004
  2003
  2002
  2001
  2000
  1999
  News
  RSS
  Calendar
  Open days
  Courses
  Congresses and symposia
  PhD-graduations and speeches

24 Nov 2008 16:00
Unit: Wageningen University
Location: Aula, building 362, Gen. Foulkesweg 1, Wageningen
Organisation: Wageningen University
Promotor: prof.dr. H.F.J. Savelkoul (Cell Biology and Immunology)
Promotor: Prof.dr. A. Pilarczyk (?)
Co Promotor: Dr.ir. G. Wiegertjes, Dr. I. Irnazarow (?)

 Diseases are an important problem in aquaculture and selection aimed at genetic disease resistance can help to improve semi-intensive carp farming systems. A natural host-parasite model of carp infected with trypanosome-like parasites was used to study competition for iron. Cells acquire iron from transferrin, which often shows genetic variation, a prerequisite for successful selection programmes. Four different gene sequences for carp transferrin were found. Although the 3-dimensional protein structures generally were conserved, differences in function between the four transferrin molecules were found. Parasites grew better in medium with serum from ‘D’-typed carp. Transferrin cleavage products, possibly formed by the parasites themselves, stimulated host macrophages to secrete high concentrations of nitric oxide, especially when derived from D-type transferrin. Fish with D-type transferrin sometimes developed higher numbers of parasites in their blood. This study provides a basis for incorporating transferrin genotypes as genetic markers in future breeding programmes of carp.

Title thesis: “Transferrin polymorphism of common carp. Link with disease resistance”
Print this activity