F. (Fabian) Blombach: Regulating protein synthesis in Archaea, the third domain of life

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19 May 2010 16:00
Unit: Wageningen University
Location: Aula, building 362, Gen. Foulkesweg 1, Wageningen
Organisation: Wageningen University
Promotor: prof.dr. J. van Oost (Microbiology)
Co Promotor: Dr.ir. S.J.J. Brouns

 Life on earth is distinguished into the three domains: Bacteria, Eukaryotes and Archaea. Bacteria are free living cells with a relatively simple organization. Eukaryotes, including fungi, plants, and animals (humans), have a more complicated cellular architecture and more sophisticated ways to regulate gene expression. Archaea, the third domain of life, share their simple organization with Bacteria. However, the basic apparatus responsible for gene expression in Archaea is closer related to its eukaryotic counterpart. We studied the function of several archaeal proteins that are present in nearly all archaeal and eukaryotic species. This indicates that they have played (and still play) an important function during the evolution of Archaea and Eukaryotes. For two of these proteins we could show that they have a function in protein synthesis, the last step of gene expression. A function related to protein synthesis could also be predicted for several other proteins.
Title thesis: "Molecular characterization of factors involved in regulation of archaeal translation"
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