As port d’entree of nutrients, the intestine plays a pivotal role in maintenance of nutrient homeostasis. In turn, dietary composition has a major influence on the overall health and functioning of the gastro-intestinal tract.
The work in our group within the Division of Human Nutrition concentrates on the molecular effects of nutrition in the small intestine and colon, the underlying mechanisms that mediate these effects, and the modulatory role of nutrition in determining the composition and activity of the microbiome. Ultimately, studies are aimed at understanding how these direct and indirect effects of nutrition contribute to the balance between (metabolic) health and disease.
In our research we use high throughput, information-dense omics technologies in combination with experiments in suitable models (e.g. cell, animal, and human models). A unique expertise is the biological interpretation of complex nutrigenomics datasets. By integrating multi-omics data sets with functional measurements, novel biological insights is gained into the molecular effects of nutrients.
The gene expression barcode 3.0: improved data processing and mining tools
Nucleic Acids Research 42 (2014)D1. - ISSN 0305-1048 - p. D938 - D943.
Gut-derived short-chain fatty acids are vividly assimilated into host carbohydrates and lipids
American Journal of Physiology. Gastrointestinal and Liver Physiology 305 (2013)G900-G910. - ISSN 0193-1857
Resistant Starch Induces Catabolic but Suppresses Immune and Cell Division Pathways and Changes the Microbiome in Proximal Colon of Male Pigs
The Journal of Nutrition 143 (2013)12. - ISSN 0022-3166 - p. 1889 - 1898.
A diet high in resistant starch modulates microbiota composition, SCFA concentrations, and gene expression in pig intestine
The Journal of Nutrition 143 (2013)3. - ISSN 0022-3166 - p. 274 - 283.
Short chain fatty acids stimulate Angiopoietin-like 4 synthesis in human colon adenocarcinoma cells by activating PPARy
Molecular and Cellular Biology 33 (2013)7. - ISSN 0270-7306 - p. 1303 - 1316.