Vitamin E supplementation in elderly lowers the oxidation rate of linoleic acid in LDL.

Summary

.Oxidation of LDL–linoleic acid (LDL–LA), a major substrate for lipid peroxidation, may be counteracted by the antioxidant vitamin E. In a 3-month randomized double-blind placebo-controlled trial in 83 apparently healthy Dutch elderly, aged 67–85 years, the direct protective effect of 100 IU vitamin E on the rate of oxidized LDL–LA was studied. The oxidation of LDL–LA was measured by its disappearance after a 5-h in vitro Cu-oxidation of LDL isolated from 1 ml plasma. In the vitamin E group, the decrease in oxidized LDL–LA of 10.4% (p