B. (Benyamin) Houshyani Hassanzadeh: Application of omics technologies for environmental risk assessment of genetically modified plants. Arabidopsis and modified defence mechanisms as a model study

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16 mrt 2012 13:30 - 16 mrt 2012 15:00
Locatie: Aula, gebouw 362, Gen. Foulkesweg 1, Wageningen
Promotor: prof.dr. R.J. Bino (Metabolomica van planten)
Promotor: prof.dr.ir. H.J. Bouwmeester
Co-Promotor: dr. ir. I.F. Kappers

 Application of omics technologies for environmental risk assessment of genetically modified plants
Developments in biotechnology are constantly increasing the opportunities for plant biotechnology applications. In response to the concerns of the society, the European Union demands a detailed environmental risk assessment before permitting the cultivation of genetically modified (GM) crops. Through the Netherlands Organisation for Scientific Research (NWO), the Dutch Government has sponsored the Ecology Regarding Gene-modified Organism (ERGO) program that aims to develop ecological guidelines for risk analysis of GM crops. In the Laboratory of Plant Physiology of Wageningen University, Benyamin Houshyani worked on one of the ERGO-projects. He developed methods to use omics platforms for the risk analysis using Arabidopsis with genetically modified insect defence mechanisms as a model. Key in his work was the establishment of a so-called baseline transcriptome and metabolome and statistical methods to compare a GM transcriptome or metabolome with this baseline. His work shows that the GM plants used in his study have substantial equivalence to the baseline metabolome and transcriptome, while lines obtained through classical breeding showed a larger variation from this baseline. We suggest that substantial equivalence of a GM line’s metabolome and/or transcriptome compared with the baseline can be used as a first-pass criterion in the assessment of GM crops, including non-target ecological effects.

Thesis title: Application of omics technologies for environmental risk assessment of genetically modified plants. Arabidopsis and modified defence mechanisms as a model study
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