PhD defence

Make it and break it. Stimuli-responsive Cyclodextrin-based Complex Coacervate Core Micelles

PhD candidate C (Camilla) Facciotti MSc
Promotor prof.dr. AH (Aldrik) Velders
Co-promotor dr. V (Vittorio) Saggiomo
Organisation Wageningen University, BioNanoTechnology
Date

Mon 16 December 2019 11:00 to 12:30

Venue Auditorium, building number 362
Generaal Foulkesweg 1
362
6703 BG Wageningen
0317-483592

Summary:

The treatment of chronic and severe disorders, such as hearth diseases, cancer and diabetes still remains challenging for health care researchers, mainly due to the poor water-solubility of the drugs and to their non-selective biodistribution. In the thesis, we developed Cyclodextrin-based Complex Coacervate Core Micelles, as a novel  nanomedicine tool to overcome these challenges. These “smart” micelles have the ability to encapsulate poor water-soluble drugs and release them under specific and controlled stimuli. Salt, pH, light and redox stimuli are some of the triggers that can be exploited to promote the disassembly of these micelle and favour the drug release. Based on the stimuli-response studies and on the encapsulation and release preliminary results shown in the thesis, we believe C4Ms might be a promising tool for drug delivery systems.