PhD defence

The selfish tumour: Cachexia-associated changes in skeletal muscle

PhD candidate M (Miranda) van der Ende MSc
Promotor prof.dr. RF (Renger) Witkamp
prof.dr.ir. J (Jaap) Keijer
Co-promotor dr. K (Klaske) van Norren
Co-promotor dr. S (Sander) Grefte
Organisation Wageningen University, Human Nutrition & Health
Date

Fri 28 January 2022 13:30 to 15:00

Venue Auditorium, building number 362

Summary

Skeletal muscle wasting is a common hallmark of (late stage) cancer, which is also called cancer cachexia. Cancer cachexia is due to the (selfish) tumour present in the body, which activates many processes in multiple organs eventually leading to the loss of muscle mass. When we unravel the mechanisms involved, treatments to prevent or counteract the cancer cachexia can be developed. In this thesis muscle cells were used to investigate the effects of secreted immune signalling molecules by the tumour cells on muscle development. Next to this, the role of mitochondria in cachexia were studied. Mitochondria are an important part of the (muscle) cells, as they generate most of the energy molecules. Lastly, the impact of vibration training was tested in an animal model of cancer cachexia. The results of these studies are described in this thesis.