Enzymes@Work - Research
Recent research highlights
Nature publication
Mical links semaphorins to F-actin disassembly.
R.J. Hung, U. Yazdani, J. Yoon, H. Wu, T. Yang, N. Gupta, Z. Huang, W.J.H. van Berkel & J.R. Terman Nature (2010) 463:823-827
JBC Paper of the Week
Identification of a gatekeeper residue that prevents dehydrogenases from acting as oxidases.
N.G. Leferink, M.W. Fraaije, H.J. Joosten, P.J. Schaap, A. Mattevi & W.J.H. van Berkel J Biol Chem (2009) 284:4392-4397
PNAS paper
Multiple pathways guide oxygen diffussion into flavoenzyme active sites.
R. Baron, C. Riley, P. Chenprakhon, K. Thotsaporn, R.T. Winter, A. Alfieri, F. Forneris, W.J.H. van Berkel, P. Chaiyen, M.W. Fraaije, A. Mattevi & J.A. McCammon Proc Natl Acad Sci USA (2009) 106:10603 -10608
Accelerated publication
Picosecond fluorescence relaxation spectroscopy of the calcium-discharged photoproteins aequorin and obelin.
B. van Oort, E.V. Eremeeva, R.B.M. Koehorst, S.P. Laptenok, H. van Amerongen, W.J.H. van Berkel, N.P. Malikova, S.V. Markova, E.S. Vysotski, A.J.W.G. Visser & J. Lee. Biochemistry (2009) 48:10486-10491
Current PhD research subjects
Enzymes@Work - Other Research projects
- Mieke Huijbers - Multi-enzyme systems involved in astin biosynthesis and their use in heterologous astin production (MESIAB). Finished, thesis date March 10, 2017
- Biocatalytic exploitation of monooxygenases
- Enzymatic cross-linking of food proteins
- Mechanism of calcium-regulated photoproteins
- Inhibition of polyphenol oxidases in food
- Stable protein-based materials
- Modular flavoenzymes