Research on the metabolism of extremophilic bacteria (Thermotoga, Caldicellulosiruptor) and archaea (Pyrococcus, Thermococcus, Sulfolobus) has been ongoing for many years.
Sugar catabolism, central metabolic pathways, hydrogen production and, most recently, archaeal lipid biosynthesis. The main focus lies on unravelling and optimising the metabolism of fermentative anaerobes, and applying these microbes to the bio-based production of fuels and chemicals. This involves the elucidation, analysis and re-routing of reactions for reductant disposal and the identification of reactions involved in ether-lipid biosynthesis. Research also includes development of generic screening and selection systems for obtaining novel enzymes or microbes with a specific product formation.