Thesis Topics

The thesis topics at the Division of Toxicology are divided in 5 major topics:

1) Risk assessment of herbal food supplements and teas

2) Mode of action of food-borne (natural) toxins

3) Alternatives to animal testing

4) The role of the gut microbiota in the toxicity of food-borne chemicals

5) Environmental toxicology

Please note that apart from the projects given below, there also possibilities for performing a thesis on a risk assessment based on literature studies at the Toxicology department.

Following next you can already find an overview of the different topics for each of the 5 themes:

1) Risk assessment of herbal food supplements and teas.

  • Mode-of-action-based risk assessment of the botanical food-borne alkenybenzene myristicin
  • Mode-of-action-based risk assessment of the botanical food-borne alkenybenzene apiol
  • Risks associated with pyrrolidizine alkaloids (PAs) in botanicals and botanical preparations including especially herbal teas and plant food supplements (PFS)
  • Safety and risk assessment of botanicals and botanical preparations
  • Risk assessment of aphrodisiac herbal products from the Ghanaian market
  • Risk assessment of human systemic exposure of the Western and Chinese population to food process contaminants
  • Development of a novel approach for the exposure and risk assessment of human systemic exposure to organophosphate pesticides via food in the Western and Chinese population
  • Risk assessment of food supplements and teas from the Indonesian market

2) Mode of action of food-borne (natural) toxins.

  • Mode of action based safety evaluation of food packaging materials
  • The role of epigenetics in differential health effects of pseudoestrogens
  • Risk-benefit analysis of bixin and norbixin from the pericarp of Bixa orellana seeds 
  • Absorption, metabolism and biological effects of furocoumarins and consequences for their risk assessment
  • Investigation of the risks and benefits of ‘Ashkulebya’ as Health Food or Therapeutic Alternative
  • The role of stability, repair and mutagenicity in the relative hazards and risks of DNA adducts formed by food-borne liver carcinogens of variable carcinogenic potential
  • Mode of action-based risk assessment of combined exposure to mycotoxins in maize and maize products
  • Unravelling the functional dynamics between the human gut microbiome and intestinal inflammatory responses
  • Prediction of chemical-induced human developmental toxicity in the Western and Chinese population, using a combined approach of in vitro toxicity testing and physiologically-based kinetic modelling

3) Alternatives to animal testing.

  • Role of polycyclic aromatic hydrocarbons in developmental toxicity of petroleum substances
  • Predicting in vivo toxicity by combining in vitro testing and a generic physiologically based kinetic (PBK) modelling approach
  • Novel in vitro bioassays for risk-benefit assessment of isothiocyanates from cruciferous vegetables
  • A novel approach for the prediction of nanoparticle uptake to improve safety evaluations of nanoparticles used in food production and preservation
  • A novel method for predicting human cardiotoxicity without animal testing
  • Development of combined in vitro-in silico methods for the risk assessment of pesticide mixtures
  • Development of a metabolic active in vitro liver model to assess the human health effects of co-exposure of plant toxins and environmental contaminants
  • The risks of food packaging materials for the Western and Chinese population

4) The role of gut microbiota in the toxicity of food-borne chemicals.

  • The role of the microbiome on plasma metabolite patterns of selected model compounds
  • Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
  • The role of the gut microbiota in the toxicity and risk assessment of food-borne chemicals
  • The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone

5) Environmental toxicology.

  • Toxicokinetics of NP accumulation in earthworms
  • Interactive effect of exposure to low levels of nanomaterials on the toxicity of environmental chemicals
  • Safety evaluation of heavy metals in acid mining water used for cultivation of sweet potatoes
  • Oxidative stress effects of heavy metals on the length of telomeres
  • Occurrence of resistance genes in small mammals in agricultural areas
  • Long term chronic exposure of small mammals to trace metals and potential effects on immune system
  • Effects of exposure scenarios on the toxicity of environmental contaminants on benthic marine organisms
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