The thesis topics at the Division of Toxicology are divided in 5 major topics:
1) Risk assessment of herbal food supplements and teas
2) Mode of action of food-borne (natural) toxins
3) Alternatives to animal testing
4) The role of the gut microbiota in the toxicity of food-borne chemicals
5) Environmental toxicology
Please note that apart from the projects given below, there also possibilities for performing a thesis on a risk assessment based on literature studies at the Toxicology department.
Following next you can already find an overview of the different topics for each of the 5 themes:
1) Risk assessment of herbal food supplements and teas.
- Mode-of-action-based risk assessment of the botanical food-borne alkenybenzene myristicin
- Mode-of-action-based risk assessment of the botanical food-borne alkenybenzene apiol
- Risks associated with pyrrolidizine alkaloids (PAs) in botanicals and botanical preparations including especially herbal teas and plant food supplements (PFS)
- Safety and risk assessment of botanicals and botanical preparations
- Risk assessment of aphrodisiac herbal products from the Ghanaian market
- Risk assessment of human systemic exposure of the Western and Chinese population to food process contaminants
- Development of a novel approach for the exposure and risk assessment of human systemic exposure to organophosphate pesticides via food in the Western and Chinese population
- Risk assessment of food supplements and teas from the Indonesian market
2) Mode of action of food-borne (natural) toxins.
- Mode of action based safety evaluation of food packaging materials
- The role of epigenetics in differential health effects of pseudoestrogens
- Risk-benefit analysis of bixin and norbixin from the pericarp of Bixa orellana seeds
- Absorption, metabolism and biological effects of furocoumarins and consequences for their risk assessment
- Investigation of the risks and benefits of ‘Ashkulebya’ as Health Food or Therapeutic Alternative
- The role of stability, repair and mutagenicity in the relative hazards and risks of DNA adducts formed by food-borne liver carcinogens of variable carcinogenic potential
- Mode of action-based risk assessment of combined exposure to mycotoxins in maize and maize products
- Unravelling the functional dynamics between the human gut microbiome and intestinal inflammatory responses
- Prediction of chemical-induced human developmental toxicity in the Western and Chinese population, using a combined approach of in vitro toxicity testing and physiologically-based kinetic modelling
3) Alternatives to animal testing.
- Role of polycyclic aromatic hydrocarbons in developmental toxicity of petroleum substances
- Predicting in vivo toxicity by combining in vitro testing and a generic physiologically based kinetic (PBK) modelling approach
- Novel in vitro bioassays for risk-benefit assessment of isothiocyanates from cruciferous vegetables
- A novel approach for the prediction of nanoparticle uptake to improve safety evaluations of nanoparticles used in food production and preservation
- A novel method for predicting human cardiotoxicity without animal testing
- Development of combined in vitro-in silico methods for the risk assessment of pesticide mixtures
- Development of a metabolic active in vitro liver model to assess the human health effects of co-exposure of plant toxins and environmental contaminants
- The risks of food packaging materials for the Western and Chinese population
4) The role of gut microbiota in the toxicity of food-borne chemicals.
- The role of the microbiome on plasma metabolite patterns of selected model compounds
- Role of the gut microbiota in the estrogenicity and related health effects of the isoflavones genistein and daidzein
- The role of the gut microbiota in the toxicity and risk assessment of food-borne chemicals
- The role of gut microbial and mammalian co-metabolism in the toxicity of (masked) zearalenone
5) Environmental toxicology.
- Toxicokinetics of NP accumulation in earthworms
- Interactive effect of exposure to low levels of nanomaterials on the toxicity of environmental chemicals
- Safety evaluation of heavy metals in acid mining water used for cultivation of sweet potatoes
- Oxidative stress effects of heavy metals on the length of telomeres
- Occurrence of resistance genes in small mammals in agricultural areas
- Long term chronic exposure of small mammals to trace metals and potential effects on immune system
- Effects of exposure scenarios on the toxicity of environmental contaminants on benthic marine organisms