E-mail: Virgil Schijns
Research interests: Immunomodulation by natural occurring inhibitors of the developing immune reaction for the rational design of new vaccines
Activation of the immune system, for the induction of specific immunity is dependent on proper signals, like soluble cytokines and membrane-expressed receptors, received in a strict time-related order. Based on the knowledge of the initiation of immune responses, new vaccines and immune potentiators can be designed in a rational way. Several new options have been developed and will be applied in model systems to increase basic understanding of the immunological mechanisms of action and for the development of new generations of vaccines to be used in different animal species and ultimately in humans.