Our research aims for nutritional improvement of diet-related (e.g. obesity, diabetes, negative energy balance) and age-related (e.g. fatigue, Alzheimer’s disease) metabolic health problems. We do this in one central research theme: Improvement of health by nutritional targeting of metabolic capacity and flexibility. We have a mitochondria-centred approach. We study white adipose tissue, muscle and other metabolic organs as well as reproduction organs.
HAP has extensive expertise in performing controlled dietary intervention studies and in the integrated metabolic, functional genomic and immunohistochemical analysis of such studies. We perform detailed mechanistic studies in (model) animals and efficacy studies in humans. Cell studies are used for mechanistic support. We focus on diets and functional food-components that affect mitochondrial functions, substrate metabolism and energy metabolism. Our expertise includes non-invasive, indirect calorimetry-based challenge tests for metabolic flexibility, for humans and animals.
Jaap Keijer: Molecular physiology of energy metabolism (Dietary Interventions - Metabolism and mitochondria - Food functionality)
Vincent de Boer: Metabolic signals and mitochondrial physiology -> (Acylation stress - Biochemical physiology - Animal and cell intervention studies)
Sander Grefte: Mitochondrial energetics in muscle and intestine physiology (Animal and cell studies - Molecular cell biology - Imaging and Respirometry)
Arie Nieuwenhuizen: Human in vivo mitochondrial fitness and biomarkers (Human interventions - NIRS - Ventilated hood - VOCs)
Evert van Schothorst: Molecular physiology and programming of substrate metabolism (Rodent dietary interventions - Indirect calorimetry - Transcriptomics - Adipose tissue)
Katja Teerds: Energy flux states in reproductive physiology (Immunohistochemistry - Endocrinology - Reproductive organs)