The resistance gene H1 confers resistance to the potato cyst nematode Globodera rostochiensis and is located at the distal end of the long arm of chromosome V of potato.
To identify the gene, genomic sequences of 14 resistance gene candidates have been obtained. Genetic analysis revealed that they all belong to the same cluster at the H1 locus. In addition, several other homologues sequences have been found in a susceptible potato genotype. In silico sequence analysis will reveal all kinds of interesting thing like their predicted gene structure, the putative amino acid sequence and under what type of selective pressure they have evolved.