Back to profile Projects - dr.ir. RJM (Richard) Kormelink Towards broad, stable and durable resistance against Tomato spotted wilt virus (tospovirus) based on intracellular innate immunity receptors. Towards broad, stable and durable resistance against Tomato yellow leaf curl virus (geminivirus) disease in tomato: studies on a Ty-1 triggered epigenetic antiviral defense mechanism. Antiviral RNAi defense and viral counterdefense by RNA silencing suppressors. The cell biology of the tospovirus intracellular replication cycle. Cap-snatching and the potential of new antiviral drug design against Influenzaviruses, Bunyaviruses and Arenaviruses. Horizontal gene transfer & persistent infections Nanobiotechnology: Virus-like particles as carrier or scaffold for epitope-based vaccines. Characterization and taxonomic classification of tospoviruses. Towards broad, stable and durable resistance against Tomato spotted wilt virus (tospovirus). Breeding of resistance against TSWV sofar is limited to the availability of only two single dominant resistance (R) genes, namely Sw5 and Tsw.