Pesticides are commonly used in the horticulture sector. While emphasis is often on the correct and efficient application of pesticides, the risk associated with application of pesticides receives less attention. Those working with pesticides need to know about occupational pesticide exposure and health risks, both for themselves as well as people living in the vicinity of places where pesticides are used. The Practical Training Centre Horticulture Kenya (PTC Horticulture) offers hands-on trainings to the horticultural sector. This manual is developed for PTC Horticulture and is about the safe and responsible use of pesticides – a guide for trainers who have to deliver trainings on ‘Occupational Pesticide Exposure & Health’ and ‘Safe & Responsible Handling of Pesticides’. This manual guides the trainers through the material, provides background and tips to the content and gives suggestions for practical assignments.