Prion protein self-peptides

Rigter, Alan; Priem, Jan; Timmers-Parohi, Drophatie; Langeveld, Jan P.M.; Zijderveld, Fred G. van; Bossers, Alex


Molecular mechanisms underlying prion agent replication, converting host-encoded cellular prion protein (PrPC) into the scrapie associated isoform (PrPSc), are poorly understood. Selective self-interaction between PrP molecules forms a basis underlying the observed differences of the PrPC into PrPSc conversion process (agent replication). The importance of previously peptide-scanning mapped ovine PrP self-interaction domains on this conversion was investigated by studying the ability of six of these ovine PrP based peptides to modulate two processes, PrP self-interaction and conversion.