The chair group Nutrition, Metabolism and Genomics of the Division of Human Nutrition and Health aims to contribute to a better understanding of the molecular mechanism of action of dietary nutrients and their impact on human health and metabolism. The group focuses on the key organs relevant for metabolism represented by the intestine, liver, adipose tissue and muscle, and the interplay between these organs and other important systems such as the microbiome.
The chair group Nutrition, Metabolism and Genomics was installed in 2000 and since then has become one of the leading groups in the area of Molecular Nutrition and Nutrigenomics. Studies within the group are geared towards expanding our understanding of the molecular physiology of nutrient metabolism in health and metabolic diseases and elucidating what key regulatory pathways go awry during disease development and aging. Particular attention is given to the role of dietary lipids. To that end, the group employs a multi-pronged approach that ranges from dietary intervention studies in human subjects to physiological experiments in transgenic animals and detailed mechanistic studies in vitro, supported by advanced nutrigenomics technology platforms.
The group contributes to the curriculum of the BSc and MSc programme in Nutrition and Health at Wageningen University & Research by offering a variety of courses on topics ranging from nutrition and health to nutritional biochemistry, advanced metabolism, and nutrigenomics.
Maternal exposure to a Western-style diet causes differences in intestinal microbiota composition and gene expression of suckling mouse pups
Molecular Nutrition & Food Research 61 (2017)1. - ISSN 1613-4125
ANGPTL4 mediates shuttling of lipid fuel to brown adipose tissue during sustained cold exposure
eLife 4 (2015). - ISSN 2050-084X - 23 p.
Gut microbiota facilitates dietary heme-induced epithelial hyperproliferation by opening the mucus barrier in colon
Proceedings of the National Academy of Sciences of the United States of America 112 (2015)32. - ISSN 0027-8424 - p. 10038 - 10043.
IL-37 protects against obesity-induced inflammation and insulin resistance
Nature Communications 5 (2014). - ISSN 2041-1723 - 12 p.
Hypoxia-inducible Lipid Droplet-associated (HILPDA) Is a Novel Peroxisome Proliferator-activated Receptor (PPAR) Target Involved in Hepatic Triglyceride Secretion
Journal of Biological Chemistry 289 (2014)28. - ISSN 0021-9258 - p. 19279 - 19293.