
Analytical Chemistry (prof. dr. M.W.F. Nielen)
The special Chair on Analytical Chemistry with special emphasis on the detection of chemical food contaminants has been established in 2007 within the Laboratory of Organic Chemistry. Focus of the Chair is on research in bioactivity-related detection and mass spectrometric identification of chemical contaminants in the food chain, ultimately leading to the identification of emerging unknown bioactive contaminants. Within this scope, innovations in ambient ionization mass spectrometry, biosensing, toxicology and microfluidics are being integrated.
In 2022 the following interrelated projects are being studied:
1. Multiplex screening using planar arrays of color-encoded microspheres
2. Advances in mass spectrometry
3. Smartphone-based food quality and safety testing
Recent publications:
A. Geballa-Koukoula, A. Gerssen, M.H. Blokland, C.T. Elliott, J. Pawliszyn, M.W.F. Nielen, “Immuno-enriched microsphere - magnetic blade spray tandem mass spectrometry for domoic acid in mussels”, Anal. Chem., 93 (2021) 15736-15743.
J. Peters, E. Ash, A. Gerssen, R. van Dam, M.C.R. Franssen, M.W.F. Nielen, “Controlled production of zearalenone-glucopyranoside standards with Cunninghamella strains using sulphate depleted media”, Toxins, 13 (2021) 366.
A. Geballa-Koukoula, A. Gerssen, M.W.F. Nielen, “From smartphone lateral flow immunoassay screening to direct MS analysis: development and validation of a semi-quantitative Direct Analysis in Real Time Mass Spectrometric (DART-MS) approach to the analysis of deoxynivalenol”, Sensors, 21 (2021) 1861.
N.G.E. Smits, M.H. Blokland, K.L. Wubs, T.F.H. Bovee, B. Albada, L.A. van Ginkel, M.W.F. Nielen, “Detection of methionine and alanine recombinant bovine somatotropins and their biomarkers in serum and milk suggests blood-milk barrier specificity for these compounds”, J. Dairy Sci., 104 (2021) 5069-5078.
P. de Haan, M.J.C. Santbergen, M. van der Zande, H. Bouwmeester, M.W.F. Nielen, E. Verpoorte, “A versatile, compartmentalised gut-on-a-chip system for pharmacological and toxicological analyses”, Sci. Rep., 11 (2021) 4920.
G.M.S. Ross, D. Filippini , M.W.F. Nielen, G.IJ. Salentijn, “Unraveling the hook effect; a comprehensive study of high antigen concentration effects in sandwich lateral flow immunoassays“, Anal. Chem., 92 (2020) 15587−15595.
G.M.S. Ross, D. Filippini , M.W.F. Nielen, G.IJ. Salentijn, “Interconnectable solid-liquid protein extraction unit and chip-based dilution for multiplexed consumer immunodiagnostics “, Anal. Chim. Acta, 1140 (2020) 190-198.
A. Geballa-Koukoula, A. Gerssen, M.W.F. Nielen, “Direct analysis of lateral flow immunoassays for deoxynivalenol using electrospray ionization mass spectrometry“, Anal. Bioanal. Chem., 412 (2020) 7547–7558.