Concerns about pharmaceuticals in aquifers are growing due to their negative impacts on water quality and ecosystems, calling for measures to reduce emissions. However, conventional wastewater treatment processes cannot remove many of the pharmaceuticals, which leads to emissions in surface waters. Dissimilatory Fe(III) or Mn(IV) reduction have been used to remove recalcitrant organic contaminants (e.g. benzene, toluene, ethylbenzene, xylenes, etc.) in aquifers. Therefore, we propose that pharmaceuticals can be removed by dissimilatory Fe(III) or Mn(IV) reduction.The aim of this research is to study whether dissimilatory Fe(III) or Mn(IV) reduction can be used to remove pharmaceuticals in wastewater effluents and to make a first step towards integrating this process into water treatment technologies.