Toxicokinetic analysis and modelling of perfluorinated compounds

Per- and polyfluoroalkyl substances (PFASs) are commonly used in various products such as food packaging materials, non-stick products (e.g. Teflon), and fire-fighting foams because of their unique water repellent, anti-stick, and fire-extinguishing properties. A key concern with PFASs is that they are persistent organic pollutants, leading to a widespread occurrence in the environment and humans.

The production of various PFASs is therefore phased out and focuses on the replacement of PFASs with less-persistent short-chain PFASs. The extent by which PFASs are accumulating in a body largely depend on the extent by which they are reabsorbed by the kidney. Organic anion transporting polypeptides (OATPs) are involved in this reabsorption.

Supervisor Ans Punt
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The goal of the current study is to measure for a range of PFASs the in vitro OATP transport kinetics using recombinant transporters and kidney cells lines. The data obtained will be integrated in a physiologically based kinetic computer models to predict blood and tissue levels of PFASs in humans, providing means to prioritise the chemicals based on their predicted extent of accumulation.