In the Toxicology team of Wageningen Food Safety Research (WFSR), we work on the development and application of in vitro novel approach methods (NAMs) for the hazard characterization of chemicals in food and feed. We also use in vitro methods to study the kinetics (intestinal uptake, (extra)hepatic metabolism, distribution and renal excretion) of chemicals, and integrate these data in physiologically based kinetic (PBK) models. The combination of these methods allows estimation of in vivo hazards, which we apply to prioritize hazards in the food and feed chain.
Examples of internships regarding toxicology:
Assess the toxic effects of chemicals in vitro using human cells
We regularly have a limited number of internship positions available on topics related to food toxicology, focusing on chemicals of relevance in food and feed. In a typical internship project, you assess the (toxic) effects of chemicals in vitro using human cells (such as assessing possible chemical-induced DNA damage, chemical effects on gene expression, etc.)
Assess the kinetics of chemicals using human cells and/or enzymes
It is also possible to perform an internship to assess the kinetics of chemicals using human cells and/or enzymes. The cell models we use allow us to study effects on, among others, the human intestine, liver, kidney, endocrine system and immune system.
Focus on computer modelling or perform a literature research
Other possibilities are to perform an internship project that focusses on computer modelling or to perform a literature research.
If you are interested in performing an internship in the Toxicology team of WFSR, please contact Jochem Louisse (jochem.louisse @ wur.nl). Please send your CV and a letter of motivation. Please provide detailed information on your availability (period and duration of internship) and your lab skills (such as cell culture skills, molecular biology skills, computer modelling skills, etc.).