The group focuses on research aimed at understanding the interaction between genotype, environment and management by using all kinds of different techniques and databases. Therefore database development, maintenance and use is an important area of attention. Furthermore statistical aspects of using large datasets especially in the field of transcriptomics and metabolomics is a major focus area.
Crops: potato, brassica, tomato and other crops of importance.
- Construction of linkage maps and QTL analysis
- Linkage Disequillibrium mapping and association mapping
- Epistatis mapping
- Genetical genomics
- Genomic prediction and selection
- Estimation of Genotype x Environment interaction
- Relating henotype data to microarray, metabolomics or proteomics data
- Methods and software for genetic analysis in polyploid species
Plant breeding has a strong link with quantitative genetics, statistics and bioinformatics, for example in identifying regions on crop genomes that are associated with observed variation in phenotypic traits, and in identifying candidate genes for these genomic regions.
Research within Plant breeding is multi-disciplinary and is dealing with a lot of different types of data, obtained from field-trials but also from high-throughput analysis of molecular markers, RNA transcripts (microarrays), proteins and secondary metabolites.
An efficient database will help in elucidating the genetics of economically important traits, in identifying molecular markers associated with agronomic traits, in allele mining and choosing interesting accessions fur further breeding with improved traits important for consumers, processors and producers.
One goal within plant breeding is to find the causal gene(s) explaining a given phenotype. Semantic web technology brings opportunities to integration data and information across spread data sources. For example, Annotex and Marker2sequence are two applications developed by Plant Breeding, which rely on this semantic web technology to integration genes, proteins, metabolites, pathways, and literature.
Contact: Richard Finkers
Current activities include combined data analysis of molecular markers, gene expression and metabolomics data and phenotype (e.g. disease resistance or product quality) scored on segregating populations of crosses. Methods being used are procedures such as random forest for classification or multiple regression in cases where the number of predictor variables (e.g. molecular markers, genes, metabolites) is much larger than the number of samples in which they have been measured (plants, tissues). Other areas of interest are modelling genotype x environment interaction, mapping and QTL analysis in single segregating populations, multiple populations or collections of germplasm. A specific focus area is also the development of a genetic analysis pipeline for polyploid crops.
Contact: Chris Maliepaard
Quantifying the Power and Precision of QTL Analysis in Autopolyploids Under Bivalent and Multivalent Genetic Models
G3 : Genes Genomes Genetics 9 (2019)7. - ISSN 2160-1836 - p. 2107 - 2122.
FitTetra 2.0 - Improved genotype calling for tetraploids with multiple population and parental data support
BMC Bioinformatics 20 (2019)1. - ISSN 1471-2105
Some thoughts on how to use markers in tetraploid rose breeding
Acta Horticulturae 1232 (2019). - ISSN 0567-7572 - p. 1 - 6.
QTL mapping of insect resistance components of Solanum galapagense
Theoretical and Applied Genetics 132 (2019)2. - ISSN 0040-5752 - p. 531 - 541.
The effect of plant development on thrips resistance in Capsicum
Arthropod-Plant Interactions 13 (2019)1. - ISSN 1872-8855 - p. 11 - 18.
Genetic variation in phytochemicals in leaves of pepper (Capsicum) in relation to thrips resistance
Arthropod-Plant Interactions 13 (2019)1. - ISSN 1872-8855 - p. 1 - 9.
Reduced phloem uptake of Myzus persicae on an aphid resistant pepper accession
Corrigendum: PolymapR - Linkage analysis and genetic map construction from F 1 populations of outcrossing polyploids
Bioinformatics 35 (2018)3. - ISSN 1367-4803 - p. 540 - 540.
QTL detection in a breeding pedigree of diploid potato
Resistentie tegen bladluizen in paprika
- Dennis van Muijen
- Gurnoor Singh
- Ran Wang
- Eliana Papoutsoglou
- Micaela Colley
- Yanlin Liao