Osteoporosis is a major health problem, and the economic burden is expected to rise due to an increase in life expectancy throughout the world. Observational evidence suggests that an elevated homocysteine concentration and poor vitamin B12 and folate status are associated with an increased fracture risk.
As vitamin B12 and folate intake and status play a large role in homocysteine metabolism, B-PROOF examines whether supplementation with these B-vitamins will reduce fracture incidence in elderly people with an elevated homocysteine concentration. Furthermore beneficial effects on neurological, cardiovascular, functional performance and metabolic outcomes are tested.
Rationale and design of the B-PROOF study, a randomized controlled trial on the effect of supplemental intake of vitamin B12 and folic acid on fracture incidence
BMC Geriatrics 11 (2011). - ISSN 1471-2318 - 10 p.
Effect of daily vitamin B-12 and folic acid supplementation on fracture incidence in elderly individuals with an elevated plasma homocysteine concentration: B-PROOF, a randomized controlled trial
American Journal of Clinical Nutrition 100 (2014)6. - ISSN 0002-9165 - p. 1578 - 1586.
Results of 2-year vitamin B treatment on cognitive performance
Neurology 83 (2014)23. - ISSN 0028-3878 - p. 2158 - 2166.
Medication-Related Fall Incidents in an Older, Ambulant Population: The B-PROOF Study
Drugs & Aging 31 (2014)12. - ISSN 1170-229X - p. 917 - 927.
Effects of 2-year vitamin B12 and folic acid supplementation in hyperhomocysteinemic elderly on arterial stiffness and cardiovascular outcomes within the B-PROOF trial
Journal of Hypertension 33 (2015)9. - ISSN 0263-6352 - p. 1897 - 1906.
Effect of vitamin B12 and folic acid supplementation on bone mineral density and quantitative ultrasound parameters in older people with an elevated plasma homocysteine level: B-PROOF, a randomized controlled trial
Calcified Tissue International 96 (2015)5. - ISSN 0171-967X - p. 401 - 409.