Want to predict the success of your large clinical trial, but cannot find a good model to predict the impact on the intestinal immune barrier and microbiota metabolome? We are starting a consortium around this topic.
With the emergence of intestine-on-chip devices, it is possible to model the crucial aspects of the human intestinal physiology (immune, microbiota, genetics) in vitro. This will improve the predictive potential of current 2D in vitro analysis for food or nutraceuticals before moving to animal or human trials. Not only is such a platform suitable for medium-throughput screening, but also can generate personalized responses to food interventions.
Design of a novel immune- and microbiota-competent intestine-on-a-chip
In this project we aim to generate a novel immune- and microbiota-competent intestine-on-a-chip. This model will be designed based on the 3-lane organoplate system of mimetas that is an optimal mixture of accessibility, simplicity and applicability. The additional lanes allow for modulation towards an immune-competent model as indicated in the below schematic figure. To support the development we will run current 2D state-of-the-art assays with industry-derived products to validate findings in the iniminiCHIP.
Invitation to collaborate
This consortium is open for participation from ingredient companies, end product companies, and biotech companies. In return for in-cash and in-kind contributions to the project, partners can specify desired topics for research, and provide direction to the research activities. Unfortunately we are not able to reply to solicitations from research institutes or enquiries from students related to this project.
Want to know more?
- dr. C.C.F.M. Govers, senior researcher Wageningen Food & Biobased Research
- dr. V.C.J. de Boer
- dr.ir. H. Bouwmeester