Call for partners: Link between carbohydrate metabolism, advanced glycation end products (AGEs), inflammation and health

Project

Call for partners: Link between carbohydrate metabolism, advanced glycation end products (AGEs), inflammation and health

Looking for effective strategies to prevent and/or treat metabolic but also neurodegenerative diseases, but don’t have the money to do research? With 50% subsidy from the Dutch TKI AND funding from the Gerrit Grijns Initiative (WUR), this could be your chance! We are starting a consortium around this topic in which three (!) PhDs are already funded. We are looking for partners with an interest in gaining strategies for developing healthy food products to join this project.

Carbohydrate metabolism

Carbohydrates are the major fuel for the body and is of importance for human health. At the same time, carbohydrate metabolism and the formation of Advanced Glycation End Products (AGEs) can trigger inflammatory processes and have been suggested to be involved in the pathogenesis of several metabolic but also neurodegenerative diseases. Accordingly, preventing AGE formation and targeting inflammation via nutrition may be an effective strategy to prevent and/or treat these diseases. In 2020, the GGI will launch a large research project in which 3 PhD candidates will study the link between carbohydrate metabolism, advanced glycation end products (AGEs), inflammation and health. Each PhD project is dedicated to a specific aim. We are looking for partners to match material and experimental costs.

3 projects, 3 PhDs, one joint effort

Project 1: Probing the link between glycaemic variability, AGEs and inflammation in humans.

Project 2: Investigate the impact of AGEs on immune function and mitochondrial energy metabolism and explore how this relates to neuro-muscular function and skeletal muscle performance markers in cross-sectional human studies of patients with different neurodegenerative diseases. 

Project 3: Development of an in vitro screening tool to modulate adverse effects of AGEs and study the potential role in neurological diseases.

Invitation to collaborate

This consortium is open for participation from ingredient companies, end product companies, and biotech companies. In return for in-cash and in-kind contributions to the project, partners can specify desired topics for research, and provide direction to the research activities. Unfortunately we are not able to reply to solicitations from research institutes or enquiries from students related to this project.

Want to know more?

Involved experts:

  • D. Esser PhD, researcher Wageningen Food & Biobased Research
  • prof.dr.ir. A.H. Kersten, Professor in Nutrition, Metabolism and Genomics, Wageningen University Human Nutrition and Health department