The treatment of chronic and severe disorders, such as hearth diseases, cancer and diabetes still remains challenging for health care researchers, mainly due to the poor water-solubility of the drugs and to their non-selective biodistribution. In the thesis, we developed Cyclodextrin-based Complex Coacervate Core Micelles, as a novel nanomedicine tool to overcome these challenges. These “smart” micelles have the ability to encapsulate poor water-soluble drugs and release them under specific and controlled stimuli. Salt, pH, light and redox stimuli are some of the triggers that can be exploited to promote the disassembly of these micelle and favour the drug release. Based on the stimuli-response studies and on the encapsulation and release preliminary results shown in the thesis, we believe C4Ms might be a promising tool for drug delivery systems.