Exploration of gut microbiota in children in low-income setting in Zambia

Summary

Good nutrition in early childhood is important for growth and development. The gut microbiota, a community of microorganisms in the digestive tract, helps in the process of extracting nutrients from food directly influencing health. In low-income setting, for example, in some communities in Zambia, achieving good nutrition is a major challenge. This PhD study explored how Mabisi, a traditional fermented milk, can support gut health in children by improving the gut environment. A field survey in a low-income Zambian community identified factors like age, antibiotic use, stunting, and fermented food consumption as associated factors shaping gut microbiota composition. Laboratory experiments further showed that both natural and sterilized Mabisi promote beneficial bacteria, increase short-chain fatty acids (SCFAs), and suggest to suppress harmful bacteria. This PhD study recommend integrating Mabisi into children’s diets is a low-cost, culturally appropriate approach to improve gut health of Zambian children.