PhD defence

Statistical models and tools for QTL mapping in multi-parent population

PhD candidate Wenhao W (Wenhao) Li MSc
Promotor Fred van Eeuwijk
Co-promotor dr.ir. MP (Martin) Boer
External copromotor dr. R.V.L Joosen
Organisation Wageningen University, Mathematical and Statistical Methods
Date

Tue 28 February 2023 16:00 to 17:30

Venue Omnia, building number 105
Hoge Steeg 2
105
6708 PH Wageningen
+31 (0) 317 - 484500
Room Auditorium

Summary

A quantitative trait locus (QTL) is a genome fragment or region that contains genes underlying quantitative traits. Multi-parent populations (MPPs) are favored in QTL mapping to uncover the genetic basis of phenotypic variation because MPPs increase genetic diversity with multiple parent sources and balance population structure through experimental crossing schemes. This research developed mixed model approaches for QTL mapping in various MPPs and uncovered complex genetic architectures such as QTL-by-family (epistasis) and QTL-by-environment interactions in specific MPPs. The robust statistical models and tools developed in this research for MPP QTL mapping benefit breeding programs and genetic research.