Towards comparative pan-genomics

Summary:

Pan-genomes have received a lot of attention in recent years. However, existing pan-genomic tools are mostly specialized to the human genome and do not scale to large collections of structurally dynamic genomes, such as plant genomes. In this thesis, we investigate computational methods to compress large sets of related genomes into a pan-genome with basic functionalities for construction, update and exploration of such pan-genomes.