Thesis subject

How do genetic variants affect α-synuclein associated pathology?

The nematode Caenorhabditis elegans is a valuable model organism for studying human Parkinson Disease associated molecular mechanisms. We use C. elegans carrying a human copy of the α-synuclein (SNCA gene) that show the characteristic protein accumulation. In C. elegans, we can study how individual genetic differences affect α-synuclein related pathology. We currently aim to find which genes in C. elegans are implicated in accelerated α-synuclein accumulation.

Techniques that will be used:

•       Recombinant inbred lines

•       gene expression analysis (qPCR)

•       Light microscopy

•       ELISA

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Period(s):

Period(s) in which subject is available: All periods

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Major(s):

This thesis topic is well suited for students of the following Bachelor programmes:

BBI - Major A Cell and Molecular Biology

BBI - Major C Human and Animal health Biology

BBT

BML

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Application:

Deadline for application for the project: at least 4 weeks

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Project:

Type of research project: Experimental work

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