Organoids - laboratory-grown, functional organ-like structures derived from stem cells - provide us with an excellent system to improve our understanding of complex genotype-phenotype relationships. It provides a powerful tool to study complex phenotypes by dissecting them into better defined molecular phenotypes, amenable to high throughput, cost-effective, large- scale phenotyping.
Organoids derived from stem cells
Organoids derived from stem cells from individual animals or humans are considered one of the most promising recent advances in life science. Host-Microbe Interactomics is a leading group in this field. The group exploited novel developments in the area of stem cell research for mice and humans and developed methods for generating organoids from pigs, chicken and bovines that closely mimic the physiology of specific tissues.
Generating biological data
These advanced stem-cell models are being used to generate biological data on intestinal functions relevant to resistance to infection, host-microbe interactions, homeostasis and feed efficiency.