PhD defence

The microbiota-gut-brain axis: the development of the gut microbiota and mental health over the first 14 years of life

PhD candidate Y (Yangwenshan) Ou MSc
Promotor prof.dr. H (Hauke) Smidt
Co-promotor dr. C (Clara) Belzer
External copromotor Carolina de Weerth
Organisation Wageningen University, Laboratory of Microbiology

Fri 14 April 2023 16:00 to 17:30

Venue Omnia
Room Auditorium


Maintaining a normal developmental trajectory of the gut microbiota is pivotal for child growth and health. A derailment of the development of the gut microbiota may trigger various temporary and enduring diseases and disorders. In the past two decades, increasing attention has been paid to the role of microorganisms in the microbiota-gut-brain axis. Through this axis and during sensitive periods such as infancy and puberty, the gut microbiota may hold more conspicuous relations to the gradually maturing host brain than at any other time point. In the research described in this thesis, we (1) described gut microbiota development in low-risk community children from birth to the age of 14 years, along with microbiota-related factors, and (2) explored relations between the gut microbiota and mental health in aspects of problem behavior, executive functions, prosociality, and social anxiety, in the same children.