GLIMP2 – An observational study to assess the role of diet and nutrient status and other lifestyle and risk factors in gestational diabetes

Gestational diabetes mellitus (GDM) is carbohydrate intolerance with first onset or diagnosis during pregnancy. It is one of the most common metabolic complications during pregnancy, affecting 1-18% of all pregnancies.

GDM increases risk of adverse pregnancy outcomes and has been related to significant short-term and long-term adverse health outcomes for both mothers and offspring, including increased risk of adverse pregnancy outcomes, type 2 diabetes and obesity. Additionally, the female offspring has an increased risk of developing GDM in later life, and, as such, an intergenerational cycle of diabesity develops.

Although current treatment is effective inreducing adverse pregnancy outcomes, prevention is more desirable as this might be more effective in reducing long term adverse health outcomes. Diet is often linked as modifiable risk factor to GDM, however there is still a knowledge gap regarding the association between diet and GDM. Key aspects of diet for prevention of GDM, the role of nutrient status and the most influential period (e.g. preconception, first trimester, second trimester) needs to be investigated before designing prevention intervention studies. The GLIMP2 study was initiated to address these aspects.

The GLIMP2 study is an observational study which aims to include 400 women of 18-40 years with a pregnancy wish. Baseline measurements are taken before pregnancy (i.e. the preconception period), with follow-up measurements during pregnancy (2x) and after delivery (1x). Measurements consist of 2 methods of dietary assessment, a physical examination, a venepuncture, 24-hour urine collection, and health and lifestyle questionnaires. Recruitment started in April 2015.

More research: Nutrition, obesity and the metabolic syndrome