Former PhD students of the sub-department of Toxicology

On this page you can find a list of PhD students who graduated in the last years. Click on the thesis title to download a PDF copy (where available) of the thesis.

2017

• Amer Al-Malahmeh (September 5): “Mode-of-action based risk assessment of the botanical foodborne alkenylbenzene myristicin”

• Abdul M. Al-Ajlouni (September 5): “Mode-of-action-based risk assessment of the botanical foodborne alkenylbenzene apiol”

• Rozaini Abdullah (March 4): “Integrated strategy for the assessment of kidney toxicity: the case of aristolochic acids"

• Rungnapa Boonpawa (January 23): “Physiologically based kinetic modeling based prediction of oral systemic bioavailability of flavonoids, their metabolites, and their biological effects”

2016

• Alexandros Sotiriou (December 21): “Novel targets for the development of drugs for Type 2 Diabetes Mellitus”
• Samantha Kloet (December 7): “In vitro assays for hazard identification of nanoparticles”
• Sunday Makama (September 15): “An in vitro-in vivo integrated approach for hazard and risk assessment of silver nanoparticles for soil organisms”
• Myrthe van den Dungen (July 8): “Persistent organic pollutants: Aberrant DNA methylation underlying potential health effects”
• Karsten Beekmann (May 18): “The influence of phase II conjugation on the biological activity of flavonoids”
• Harrie Buist (May 13): “Dermal absorption and toxicological risk assessment: Pitfalls and Promises”
• Marije Strikwold (April 29): “Replacing animal experiments in developmental toxicity testing of phenols by combining in vitro assays with physiologically based kinetic (PBK) modelling”
• Hequn Li (April 4): “Alternative testing strategies for predicting developmental toxicity of antifungal compounds”

2015

• Abraham Martijn (December 4): “Impact of the water matrix on the effect and the side effect of MP UV/H2 O2 treatment for the removal of organic micropollutants in drinking water production”
• Arif Islam (October 9): “Improvement of risk assessment by integrating toxicological and epidemiological approaches: The case of isoflavones”
• Jonathan Nicolas (October 7): “Innovative mode of action based in vitro bioassays for detection of marine neurotoxins”
• Barae Jomaa (June 5): “Thyroid in a jar: Towards and integrated in vitro testing strategy for thyroid-active compounds”
• Elise Hoek (May 13): “Unravelling mechanisms of dietary flavonoid-mediated health effects: effects on lipid metabolism and genotoxicity”
• Reiko Kiwamoto (May 13): “Physiologically based in silico modelling to examine DNA adduct formation by different food-borne α,β-unsaturated aldehydes at realistic low dietary exposure levels”
• Agata Walczak (January 5): “Development of an integrated in vitro model for the prediction of oral bioavailability of nanoparticles”

2014

• Nynke Evers (June 13): “Factors influencing ER subtype-mediated cell proliferation and apopotosis”
• Suzanne van den Berg (June 2): “New concepts for risk and safety assessment of botanicals and botanical preparations including plant food supplements (PFS)”
• Noortje Reeuwijk (May 23): “Contaminants in food supplements and associated health risks”

2013

• Wasma Al-Husainy (December 10): “Matrix modulation of the toxicity of alkenylbenzenes, studied by an integrated approach using in vitro, in vivo and physiologically based biokinetic (PBBK) models”
• Erryana Martati (October 31): “Physiologically based biokinetic (PBBK) modeling and validation of dose-, species-, interindividual- and matrix dependent effects on the bioactivation and detoxification of safrole”
• Mauricio Montano (July 5): “Towards a realistic risk characterization of complex mixtures using in vitro bioassays”
• Si Wang (June 20): “Toxicogenomics-based in vitro alternatives for estrogenicity testing”
• Linda Gijsbers (March 8): “In vitro reporter gene assays for assessment of PPAR- and Nrf2-mediated health effects of tomato and its bioactive constituents”
• Merel van der Ploeg (January 30): “Unravelling hazards of nanoparticles to earthworms, from gene to population”
• Ala Al Subeihi (January 28): “Physiologically based kinetic (PBK) models to give insight into dose-, species-, matrix- and interindividual human variation-dependent effects on bioactivation and detoxification of methyleugenol”

2012

• Henrique Anselmo (December 18): “Effects of Marine Persistent Organic Pollutants on Early Life Development and Metamorphosis of Echinoids”
• Jaime Pais de Freitas (December 17): “Development and validation of in vitro bioassays for thyroid hormone receptor mediated endocrine disruption”
• Sourav Bhattacharjee (September 7): “Development and hazard assessment of nanoparticles”
• Jochem Louisse (May 25): “Integrated in vitro-in silico models for predicting in vivo developmental toxicity: facilitating non-animal based safety assessment”
• Alicia Paini (March 26): “Generation of in vitro data to model dose dependent in vivo DNA binding of genotoxic carcinogens and its consequences: the case of estragole”

2011

• Niek C.A. van de Pas (December 23): “A physiologically based kinetic model for the prediction of plasma cholesterol concentrations in mice and man”
• Eric Penders (December 12): “Development of aquatic biomonitoring models for surface waters used for drinking water supply”
• Walter Westerink (December 4): “The development of improved and new in vitro assays for detecting the genotoxic and non-genotoxic carcinogenic potential of chemicals in the discovery phase of drug development”

2010

• Ana María Sotoca Covaleda (September 14): “Unravelling the mechanism of differential biological responses induced by food-borne xeno- and phyto-estrogenic compounds”
• Walter Brand (May 28): “Increasing hesperetin bioavailability by modulating intestinal metabolism and transport”

2009

• Cor Schipper (December 8): “Assessment of chemical contaminants in dredged material on marine ecosystems and human health”
• Ans Punt (June 15): “Physiologically based biokinetic (PBPK) models to characterize dose-dependent effects, species differences, and interindividual human variation in bioactivation and detoxification of estragole”
• Martijn Vermeulen (February 13): “Isothiocyanates from Cruciferous Vegetables: Kinetics, Biomarkers and Effects” 

2008

• Elton Zvinavashe (December 16): “The potential of computer-based quantitave structure activity approaches for predicting acute toxicity of chemicals”
• Marcel ter Veld (December 5): “In vivo relevance of in vitro detected estrogenic effects of food associated compounds”
• Rinus Bogers (November 12): “Markers of endocrine disruption in fish”
• Wiratno (October 22): “Effectiveness and Safety of Botanical Pesticides Applied in Black Pepper (Piper negrum) Plantations”
• Esther Kok (June 13): “The application of transcriptomics in the comparative safety assessment of (GMO-deerived) plant products”
• M.J. Tijhuis: “Fruits and vegetables, detoxification genes and intermediate endpoints in colorectal cancer prevention”

2007

• Yuen Yee Hilz (December 7): “in vitro and in vivo interplay between NAD(P)H: quinone oxidoreductase 1 and flavonoids”
• Vincent de Boer (May 11): “Towards functional effects of polyphenols: modulation of energy metabolism revealed”
• Ashwin Dihal (June 8): “Biomarkers of quercetin-mediated modulation of colon carcinogenesis”
• Suzanne Jeurissen (June 15): “Bioactivation and genotoxicity of the herbal constituents safrole, estragole and methyleugenol”
• Maaike Schutte (October 19): “Effect of (mixtures of) flavonoids on the in vitro and in vivo bioavailability of 2-mino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) : a biologically based modelling approach”

2006

• Merijn Schriks (October 10): “Novel in vitro, ex vivo and in vivo assays elucidating the effects of endocrine disrupting compounds (EDCs) on thyroid hormone action”
• Aukje Steensma (May 17): “Bioavailability of genistein and its glycoside genistin”
• Hester van der Woude (March 7): “Mechanisms of toxic action of the flavonoid quercetin and its phase II metabolites”
• Arno Gutleb (February 2): “Detecting the effects of environmentally relevant concentrations of thyroid hormone disrupting compounds on amphibian development”
• Toine F.H Bovee (June 23): “Development, validation and routine application of the in vitro REA and DR-CALUX reporter gene bioassays for the screening of estrogenic compounds and dioxins in food and feed”

2005

• Jelmer van Zanden (June 10): “Modulation of multidrug resistance by flavonoids. Inhibitors of glutathione conjugation and MRP-mediated transport”
• Maria J.H. Moonen (May 30): “Novel oxygenases acting on phenolic compounds”

2004

• Marjan van Erk: “Role of phytochemicals in colon cancer prevention. A nutrigenomics approach”
• Wilbert H.M. Heijne: “Toxicogenomics: Applications of new functional genomics technologies in toxicology”
• Miriam Verwei: “Bioavailability of folate from fortified milk products”

2003

• Barry  Blankvoort: “Development of an endogenous androgen receptor-mediated luciferase expression assay (AR-LUX) for interactive androgenic action”
• Yvonne Dommels: “Effects of n-6 and n-3 polyunsaturated fatty acids on colorectal carcinogenesis”

2002

• Timo Hamers: “Toxic potency and effects of diffuse air pollution”
• Daphne de  Roode: “The chicken embryo bioassay as a tool to assess the possible toxic effects of persistent organic pollutants (POPs): a study with special reference to thiamine deficiency, EROD induction and the bursa of Fabricius”
• Eric Vis: “Influence of dietary protein sources on putative in vitro and in vivo colon cancer biomarkers”