Publications of Enzyme Reactions and Bio-Separations

Modelling thermal interactions in a heated microsystem. Swarts, JW, Janssen, AEM, Boom, RM (2010) Chemical Engineering Research and Design, accepted

Effect of diffusion on enzyme activity in a microreactor. Swarts, JW, Kolfschoten, RC, Jansen MCAA, Janssen, AEM, Boom, RM (2010)  Chemical Engineering Journal 162: 301-306 Full Text

In-line quantification of peroxidase-catalyzed cross-linking of a-lactalbumin in a microreactor. Heijnis, W.H., Wierenga, P.A., Janssen, A.E.M., van Berkel, W.J.H., Gruppen, H. (2010) Chemical Engineering Journal 157: 189-193 Full Text

A three-phase microfluidic chip for rapid sample clean-up of alkaloids from plant extracts. Tetala, K.K.R., Swarts, J.W., Bo, C., Janssen, A.E.M., Beek, T.A. (2009) Lab on a Chip 9: 2085-2092 Full Text

Pressure aided proteolysis of ß-casein. Bruins, ME, Creusot, N, Gruppen, H, Janssen, AEM, Boom, RM (2009) J. Agric. Food Chem. 57: 5529-5534. Full Text

Inactivation and conformational studies of β-glucosidase from Pyrococcus furiosus in the pressure-temperature-plane. M.E. Bruins, F. Meersman, A.E.M. Janssen, K. Heremans, R.M. Boom. (2009) FEBS journal 276: 109-117 Full Text

Temperature effects during practical operation of microfluidic chips. Swarts, J.W., Janssen, A.E.M., Boom, R.M. (2008) Chem. Eng. Sci. 63: 5252-5257. Full Text

Methylation in methanol-water mixtures: the effect of solvent quality and high-pressure. M.E. Bruins, K.M. Bekers, A.E.M. Janssen, R.M. Boom. (2008) Biophysical Chemistry. 134: 207-213. Full Text

Towards an optimal process for gelatinisation and hydrolysis of highly concentrated starch-water mixtures with α-amylase from B. licheniformis. Baks T, Kappen FHJ, Janssen AEM, Boom RM. (2008) J Cereal Sci. 47 (2): 214-225 Full Text

Comparison of two-phase lipase-catalyzed esterification on micro and bench scale. Swarts, J.W., Vossenberg, P., Meerman, M.H., Janssen, A.E.M., Boom, R.M. (2008) Biotechnol. Bioeng. 99(4): 855-861 Abstract : Full Text 

Modeling of product removal during enzymatic conversions by using affinity molecules. Halsema, D.W.G., Janssen, A.E.M., Boom, R.M. (2007) Biotechnol. Progr. 23: 1378-1382. Abstract : Full Text

The effect of pressure and temperature on the gelatinisation of starch at various starch concentrations. Baks T, Bruins ME, Janssen AEM, Boom RM. (2008) Biomacromolecules. 9: 296-304  Abstract : Full Text

Effect of gelatinisation and hydrolysis conditions on the selectivity of starch hydrolysis with a-amylase from B. licheniformis. Baks T, Bruins ME, Matser AM, Janssen AEM, Boom RM. (2008) J. Agric. Food Chem. 56: 488-495. Abstract : Full Text

A Stochastic model for predicting dextrose equivalent and saccharide composition during enzymatic starch hydrolysis. Besselink T, Baks T, Janssen AEM, Boom RM. (2008). Biotechnology and Bioengineering 100 (4): 684-697 Full Text

Comparison of methods to determine the degree of gelatinisation for both high and low starch concentrations.  Baks, T., Ngene, I.S., van Soest, J.G., Janssen, A.E.M., Boom, R.M. (2007) Carbohydr. Polym. 67: 481-490. Abstract : Full Text

Buffer selection for HP treatment of biomaterials and its consequences for enzyme inactivation studies. M.E. Bruins, A.M. Matser, A.E.M. Janssen, R.M. Boom. (2007) High Pressure Research. 27(1): 97-104. Full Text

Enzymatische reacties bij hoge druk. Bruins, M.E., Janssen, A.E.M., Boom, R.M., Matser, A.M. (2007) NPT Procestechnologie 2, april 2007, pp 11-13.

A kinetic model to describe the effect of small carbohydrates on  a-amylase activity measurements. Baks, T., Janssen, A.E.M., Boom, R.M. (2006) Biotechnol. Bioeng. 94: 431-440 Abstract : Full Text

Equilibrium shifts in enzyme reactions at high pressure. Bruins, M.E., Janssen, A.E.M., Boom, R.M., (2006) J. Mol. Catal. B. Enzymatic.39: 124-127 Full Text

The effect of carbohydrates on α-amylase activity measurements. Baks, T., Janssen, A.E.M., Boom, R.M., (2006) Enzyme Microb. Technol. 39: 114-119  Full Text

Oligosaccharide synthesis by the hyperthermostable b-glucosidase from Pyrococcus furiosus: kinetics and modeling. Bruins, M.E., Strubel, M., van Lieshout, J.F.T., Janssen, A.E.M., Boom, R.M. (2003) Enzyme Microb. Technol. 33: 3-11. Abstract ; Full Text

Maillard reactions and increased inactivation during oligosaccharide synthesis by a hyperthermophilic glycosidase. Bruins, M.E.,Van Hellemond E.W., Janssen, A.E.M., Boom, R.M. (2003) Biotechnology Bioeng. 81: 546-552 Abstract ; Full Text

Enzyme inactivation due to Maillard reactions during oligosaccharide synthesis by a hyperthermophilic glycosidase: influence of enzyme immobilisation. Bruins, M.E. Thewessen, A.J.H., Janssen, A.E.M., Boom, R.M. (2003) J. Mol. Catal. B: enzymatic. 21: 31-34 Abstract ; Full Text

Solvent selection for solid-to-solid synthesis. Ulijn Rein V; De Martin Luigi; Gardossi Lucia; Janssen Anja E M; Moore Barry D; Halling Peter J (2002) Biotechnol. Bioeng. 80, 509-515. Abstract ; Full Text

Enzymatic synthesis of beta-lactam antibiotics via direct condensation. Ulijn R V; De Martin L; Halling P J; Moore B D; Janssen A E M (2002) J. Biotechnol., 99: 215-222. Abstract ; Full Text

Reversible Acetonitrile-Induced Inactivation/Activation of Thermolysin. Ulijn, R.V., Anja E. M. Janssen, Barry D. Moore, Peter J. Halling, Sharon M. Kelly, Nicholas C. Price (2002) ChemBioChem 3: 1112-1116 Abstract ; Full Text

A single aqueous reference equilibrium constant for amide synthesis-hydrolysis. Ulijn, R.V., Moore, B.D., Janssen, A.E.M., Halling, P.J. (2002) J. Chem. Soc., Perkin Trans. 2: 1024-1028.

Modelling of the enzymatic kinetically controlled synthesis of cephalexin -Influence of diffusion limitation-. Schroën, C.G.P.H., C.B. Fretz, V.H. DeBruin, W. Berendsen, H.M. Moody, E.C. Roos, J.L. VanRoon, P.J. Kroon, M. Strubel, A.E.M. Janssen, J. Tramper. (2002) Biotechnol. Bioeng. 80: 331-340. Abstract ; Full Text

Enhancement of enzymatic adipyl-7-ADCA hydrolysis. Schroën, C.G.P.H., P.J. Kroon, J.M. VanderLaan, A.E.M. Janssen, J. Tramper. (2002) Biocatalysis and Biotransformation. 20: 369-375 Abstract ; Full Text

Integrated reactor concepts for the enzymatic kinetic synthesis of cephalexin. Schroën, C.G.P.H., V.A. Nierstrasz, R. Bosma, P.J. Kroon, P.S. Tjeerdsma, E. DeVroom, J.M. VanderLaan, H.M. Moody, H.H. Beeftink, A.E.M. Janssen, J. Tramper. (2002) Biotechnol. Bioeng. 80: 144-155. Abstract ; Full Text

Cephalexin synthesis by immobilised penicillin G acylase under non-isothermal conditions: reduction of diffusion limitation. Schroen, C.G.P.H., M.S. Mohy Eldin, M.S., Janssen, A.E.M., Mita, G.D., Tramper, J. (2001) J. Mol. Catal. B: Enzymatic 15: 163-172. Abstract ; Full Text

Predicting when precipitation-driven synthesis is feasible: Application to Biocatalysis. Ulijn, R.V. Janssen, A.E.M., Moore, B.D., Halling, P.J. (2001) Chem. Eur. J. 7: 2089-2098. Abstract ; Full Text

Thermozymes and their applications. Bruins, M.E., Janssen, A.E.M., Boom, R.M. (2001) Biochem. Biotechnol. 90:155-186. Abstract ; Full Text

Modeling of the enzymatic kinetic synthesis of cephalexin. Influence of substrate concentration and temperature. Schroen, C.G.P.H., V.A. Nierstrasz, H.M. Moody, M.J. Hoogschagen, P.J. Kroon, R. Bosma, H.H. Beeftink, A.E.M. Janssen, J. Tramper. (2001) Biotechnol. Bioeng. 73: 171-178. Abstract ; Full Text

Enzymatic synthesis of oligosaccharides: Product removal during a kinetically controlled reaction. Boon, M.A., K. van’t Riet, A.E.M. Janssen (2000) Biotechnol. Bioeng. 70: 411-420. Abstract ; Full Text

Equilibrium position, kinetics, and reactor concepts for the adipyl-7-ADCA-hydrolysis process. Schroen, C.G.P.H., VandeWiel, S., Kroon, P.J., DeVroom, E., Janssen, A.E.M., Tramper, J. (2000) Biotechnol. Bioeng. 70: 654-661. Abstract ; Full Text

Immobilization of penicillin G acylase onto chemically grafted nylon particles. Mohy Eldin, M.S., Schroen, C.G.P.H., Janssen, A.E.M., Mita, D.G., Tramper, J. (2000) J. Mol. Catal. B: enzymatic 10: 445-451. Abstract ; Full Text

Effect of temperature and enzyme origin on the enzymatic synthesis of oligosaccharides. Boon, M.A., Janssen, A.E.M., van ‘t Riet, K. (2000) Enzyme Microb. Technol. 26: 271-281 Abstract ; Full Text

Non-isothermal cephalexin hydrolysis by penicillin G acylase immobilized on grafted nylon membranes. Mohy Eldin, M.S., Santucci, M., Rossi, S., Bencivenga, U., Canciglia, P., Gaeta, F.S., Tramper, J., Janssen, A.E.M., Schroen, C.G.P.H., Mita, D.G. (2000) J. Mol. Catal. B: enzymatic 8: 221-232. Abstract ; Full Text

The nature of fatty acid modifies the equilibrium position in the esterification catalysed by lipase. Flores, M.V., Sewalt, J.J.W., Janssen, A.E.M., van der Padt, A. (2000) Biotechnol. Bioeng. 67: 364-371 Abstract ; Full Text

Modelling and parameter estimation of the enzymatic synthesis of oligosaccharides by b-galactosidase from Bacillus circulans. Boon, M.A., Janssen, A.E.M. and Van der Padt A. (1999) Biotechnol. Bioeng. 64: 558-567. Abstract ; Full Text

Thermodymically controlled synthesis of cefamandole. Nierstrasz, V.A., Schroën, C.G.P.H., Bosma, R., Kroon, P.J., Beeftink, H.H., Janssen, A.E.M., Tramper, J. (1999) Biocat. Biotransform. 17: 209-223.

Kinetics of lipase-catalysed esterification in organic media: correct model and solvent effects on parameters. Janssen, A.E.M., Sjursnes, B., Vakurov, A.V., Halling, P.J. (1999) Enzyme Microb. Technol. 24: 463-470. Abstract ; Full Text

Thermodynamically controlled synthesis of b-lactam antibiotics. Equilibrium concentration and side-chain properties. Schroën, C.G.P.H., Nierstrasz, V.A., Kroon, P.J., Bosma, R., Janssen, A.E.M., Beeftink, H.H., Tramper, J. (1999) Enzyme Microb. Technol. 24: 498-506 Abstract ; Full Text

Synthesis of oligosaccharides catalysed by the thermostable b-glucosidase from Pyrococcus furiosus. Boon, M.A., J. van der Oost, W.M. de Vos, A.E.M. Janssen and K. van ‘t Riet (1998) Appl. Biochem. Biotechnol. 75: 269-278.

Water activity fails to predict critical hydration level for enzyme activity in polar organic solvents: Interconversion of water concentrations and activities. Bell, G., Janssen, A.E.M., Halling, P.J. (1997) Enzyme Microb. Technol. 20: 471-477. Abstract ; Full Text

Substrate specificity and kinetics of Candida rugosa lipase in organic media. Janssen, A.E.M., Vaidya, A.M., Halling, P.J. (1996) Ann.N.Y. Acad. Sci.799: 257-261. Abstract ; Full Text

Substrate specificity and kinetics of Candida rugosa lipase in organic media. Janssen, A.E.M., Vaidya, A.M., Halling, P.J. (1996)Enzyme Microb. Technol. 18: 340-346. Abstract ; Full Text

Prediction of the reaction equilibrium of biocatalytic reactions in aqueous-organic two-phase systems. Janssen, A.E.M., A. van der Padt and K. van 't Riet (1995) Biocatalysis and Biotransformations 12: 223-240.

Specificities of enzymes "corrected for solvation" depend on the choice of the standard state. Janssen, A.E.M., and P.J. Halling (1994) J. Am. Chem. Soc. 116: 9827-9830. Abstract ; Full Text

The effect of organic solvents on the equilibrium position of enzymatic acylglycerol synthesis. Janssen, A.E.M., A. van der Padt, H.M. van Sonsbeek and K. van 't Riet (1993) Biotechnol. Bioeng. 41: 95-103. Abstract ; Full Text

Solvent effects on the equilibrium position of lipase-catalyzed esterification of decanoic acid and various alcohols. Janssen, A.E.M., N. Wessels Boer, K. van 't Riet (1993) Biocatalysis 8: 133-153.

Solvent effects on lipase-catalyzed esterification of glycerol and fatty acids. Janssen, A.E.M., A. van der Padt, K. van 't Riet (1993) Biotechnol. Bioeng. 42: 953-962. Abstract ; Full Text