Disease aetiology and prevention
Non-communicable diseases are largely caused by an unhealthy diet and lifestyle. We study the role of nutrition and lifestyle factors in the aetiology of cardiovascular diseases and cancer by means of epidemiological studies and randomized trials, underpinned with research on pathophysiological mechanisms.
This is done by means of observational epidemiological studies and randomized trials in individuals who are at (high) risk of disease, making use of advanced methods and data-analysis techniques. Genetic factors and biomarkers of health and disease are measured to elucidate underlying disease processes. Systematic reviews and meta-analyses of observational studies and trials are conducted to summarise existing scientific evidence. Findings from different levels of research are integrated and translated into guidelines and recommendations, whenever possible.
Nutrition and cardiovascular diseases
Our research on cardiovascular diseases mainly focuses on nutrition in relation to coronary heart disease and stroke. Research is done on cardiovascular disease endpoints and on blood pressure, serum lipids, kidney function and pathophysiological processes, such as endothelial dysfunction and inflammation. Cardiovascular diseases are primarily caused by an unhealthy diet and lifestyle. We study a wide range of dietary factors, including minerals, salt, fatty acids, protein, polyphenols, dairy products, plant foods, and dietary patterns.
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Nutrition and Cancer
Our research on cancer mainly focusses on nutrition and other lifestyle factors in relation to the development and progression of colorectal cancer and breast cancer. We study a wide range of dietary exposures, including B-vitamins, vitamin D, dietary supplements, body composition and dietary patterns. Endpoints that are studied are cancer incidence and cancer survival, but we also investigate underlying mechanisms, e.g. by evaluating diet-gene interactions, epigenetics, gene-expression, and inflammatory markers. Our studies are conducted in high-risk individuals, cancer patients and the general population.
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Current key projects
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Cardiovascular Health: Relevance of cardiovascular function markers. Sodium and potassium on vascular and renal function.
There is a great need to establish the relevance of vascular function markers to evaluate the impact or potential of diet on cardiovascular health.... -
Alpha Omega Trial on n-3 fatty acids and cardiovascular diseases
The Alpha Omega Trial was set up to assess the effect of omega-3 fatty acids on major cardiovascular events in 4,837 post-myocardial infarction... -
Cardiovascular health: Relevance of cardiovascular function markers. Polyphenol intake and vascular function.
There is a great need to establish the relevance of vascular function markers to evaluate the impact or potential of diet on cardiovascular health.... -
GeoLynch - Genetic, Environmental and Other influences among persons with LYNCH syndrome
In the GeoLynch study we would like to learn more about the influence of dietary and lifestyle factors on the development of tumours among persons... -
COLON study - COlorectal cancer: Longitudinal, Observational study on Nutritional and lifestyle factors that influence colorectal tumour recurrence, survival and quality of life
The purpose of the COLON study is to provide a scientifically substantiated answer to the question whether nutrition and lifestyle affect the disease...