
Newcastle disease
Newcastle disease (ND) is a contagious disease affecting many species of birds. Infection with this virus occurs through contact with sick birds, contaminated material or the air. Wageningen Bioveterinary Research (WBVR) conducts research into this disease.
In cage and aviary birds, and wild birds the outcome of the disease depends much more on the type of bird. A death rate of almost 100 percent can occur in unvaccinated poultry flocks.
Newcastle disease infection
Newcastle disease is caused by a virus of the family Paramyxoviridae. Members of this virus family have a single stranded, linear, RNA. Severity of the disease is extremely variable from subclinical until high mortality depending on the strain of virus, species and age of bird, concurrent disease, and pre-existing immunity. Virulent strain of the Newcastle disease virus cause severe disease of the digestive, respiratory and/or nervous systems in particular in susceptible domestic poultry.
Spread of Newcastle disease
The disease is transmitted through infected birds' droppings and secretions from the nose, mouth, and eyes or indirect by exposure to materials contaminated with these secretions. The incubation period of the disease in poultry flocks ranges from 2 to 15 days.
Publications
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Intranasal adminstration of a live-attenuated recombinant newcastle disease virus expressing the SARS-CoV-2 Spike protein induces high neutralizing antibody levels and protects from experimental challenge infection in hamsters
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Correction to: Predominance of Fourth Panzootic Newcastle Disease Virus Subgenotype VII.1.1 in Iran and Its Relation to the Genotypes Circulating in the Region
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Predominance of Fourth Panzootic Newcastle Disease Virus Subgenotype VII.1.1 in Iran and Its Relation to the Genotypes Circulating in the Region
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Rapid Generation of a Recombinant Genotype VIII Newcastle Disease Virus (NDV) Using Full-Length Synthetic cDNA
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Molecular and virological characterization of the first poultry outbreaks of Genotype VII.2 velogenic avian orthoavulavirus type 1 (NDV) in North-West Europe, BeNeLux, 2018
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Development of an effective and stable genotype-matched live attenuated newcastle disease virus vaccine based on a novel naturally recombinant malaysian isolate using reverse genetics
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Exploring the prospects of engineered Newcastle disease virus in modern vaccinology
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Newcastle disease, other avian paramyxoviruses, and avian metapneumovirus infections
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Genotype Diversity of Newcastle Disease Virus in Nigeria : Disease Control Challenges and Future Outlook
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An avian influenza virus H6N1 outbreak in commercial layers: case report and reproduction of the disease