Free radical theory of ageing

Description:

As side product of the energy metabolism in the mitochondria reactive oxygen species are formed that can interact with nucleic acids, proteins and other cell components and with accumulating damage the energy metabolisms is disrupted and finally the cell or organisms stops growing and dies. How can an organism cope with the damage caused by the free radicals, prevent it or repair it? With the model organism P. anserina we can study the ageing process and the influence of free radicals on lifespan.

Used skills:

microbiological and molecular biology skills, some statistical analysis to interpret the results.

Requirements:

Molecular and Evolutionary Ecology (GEN20304) and Genetic Analysis Tools and Concepts (GEN30306) are good preparations.

Reference:

(i) Harman, D. (1956) Ageing – A theory based on free radical and radiation theory. J. Gerontol. 11: 298-300; (ii) Dufour E et al. 2000. A causal link between respiration and senescence in Podospora anserina. PNAS 97: 4138-4143