Plant Biotechnology meets Immunology. Plant-based expression of immunologically relevant proteins

PhD defence

PhD defence Ruud Wilbers

Title Thesis: Plant Biotechnology meets Immunology. Plant-based expression of immunologically relevant proteins.

PhD candidate dr.ir. RHP (Ruud) Wilbers
Promotor prof.dr.ir. J (Jaap) Bakker
Co-promotor dr.ir. A (Arjen) Schots
prof.dr.ir. G (Geert) Smant
Organisation Wageningen University, Laboratory of Nematology
Date

Fri 23 October 2015 13:30 to 15:00

Venue Aula, gebouwnummer 362
Generaal Foulkesweg 1
362
6703 BG Wageningen
0317-483592
The incidence of inflammatory disorders in industrialized countries has dramatically increased over the last decennia, which is believed to result from a change in life-style. Treatment of these inflammatory disorders relies on the intervention in immune responses thereby restoring homeostasis. Currently, many inflammatory disorders are treated with broad-acting immunosuppressive drugs or monoclonal antibodies that specifically target pro-inflammatory molecules of the immune system. An alternative therapeutic approach would be to use immunomodulatory proteins that are naturally involved in re-establishing immune homeostasis. This thesis describes the plant-based expression of a variety of immunomodulatory cytokines that may be used as biopharmaceutical proteins in the future. Furthermore, this thesis contains a pioneering chapter on the plant-based expression of immunomodulatory helminth-secreted glycoproteins. In parallel to these plant biotechnological research lines, we also developed an in vitro model system based on mouse bone marrow-derived cells to study immunological responses.