Publication: 3D Domain Swapping Causes Extensive Multimerisation of Human Interleukin-10 When Expressed In Planta

Published on
November 7, 2012

Two is a couple, three is a crowd, four is too many and more than five is not allowed!

IL-10/Picture: Lotte Westerhof
IL-10/Picture: Lotte Westerhof

In this manuscript we show how high expression of naturally dimeric human interleukin-10 in plants results in aggregation by extensive multimerisation. Through protein engineering we created a stable dimeric form of human interleukin-10 that retained its activity.