There is a great need to establish the relevance of vascular function markers to evaluate the impact or potential of diet on cardiovascular health. Therefore, the Top Institute Food and Nutrition carries out a large multidisciplinary programme on cardiovascular health, which is a collaborative effort of research groups in Wageningen, Maastricht and Groningen.
The overall aim of the project is to substantiate the validity and relevance for cardiovascular health of selected diet-sensitive vascular function markers. Central research questions are if, how, and to what extent diet-induced changes in vascular function markers predict cardiovascular health outcomes in humans. A multidisciplinary approach will be used to address these questions, and to demonstrate and unravel mechanistic cause-effect relationships of dietary ingredients with vascular function markers, endothelial (dys)function, blood pressure, other established cardiovascular risk factors, organ (dys)function, and disease risk.
This part of the project studies associations of vitamin K intake and flavonoid intake with risk of cardiovascular outcomes in several national and international cohort studies.
Two related projects focus on the role of polyphenol intake on vascular function and the role of sodium and potassium intake on vascular and renal function.