Jaap Keijer

Jaap Keijer participates in the Mitofood project; a research community for nutritional optimization of mitochondrial function for health promotion and disease resistance.

Prof. dr. Jaap Keijer

Wageningen University
Animal Sciences Group
Marijkeweg 40
6709 PG  Wageningen
The Netherlands
Tel +31 317 84136
Fax + 31 317 484077

E-mail: jaap.keijer@wur.nl

Website: www.molecularphysiology.eu

Expertise

Mechanistic physiology focussing on energy metabolism, adipose tissue and lung and modulation by bioactive food components. Transcriptomics and functional, biochemical and histochemical assays are applied to understand the effects of dietary exposure (polyphenols, carotenoids and other bioactive food components) on energy metabolism. Studies are performed in humans, animals and cells.

Relevant projects and functions

  • WP leader of Bioclaims
  • Member of the editorial board of 'Genes and Nutrition'

Selected publications

  1. "Induction of lipid oxidation by polyunsaturated fatty acids of marine origin in small intestine of mice fed a high-fat diet", Van Schothorst EM, Flachs P, Franssen-van Hal NL, Kuda O, Bunschoten A, Molthoff J, Vink C, Hooiveld GJ, Kopecky J, Keijer J. BMC Genomics. 2009 10:110.
  2. "Beta-carotene affects oxidative stress-related DNA damage in lung epithelial cells and in ferret lung", Van Helden YG, Keijer J, Heil SG, Picó C, Palou A, Oliver P, Munnia A, Briedé JJ, Peluso M, Franssen-van Hal NL, van Schooten FJ, Godschalk RW. Carcinogenesis. 2009 30:2070-6.
  3. "Transcriptome analysis in benefit-risk assessment of micronutrients and bioactive food components", Keijer J, van Helden YG, Bunschoten A, van Schothorst EM. Mol Nutr Food Res. 2009 Dec 18. PMID:20024935
  4. "Mitochondrial (dys)function in adipocyte (de)differentiation and systemic metabolic alterations", De Pauw A, Tejerina S, Raes M, Keijer J, Arnould T. Am J Pathol. 2009 175: 927-39.