Jan Nedergaard

Jan Nedergaard participates in the Mitofood project; a research community for nutritional optimization of mitochondrial function for health promotion and disease resistance.

Prof. dr. Jan Nedergaard

The Wenner-Gren Institute
The Arrhenius Labs F3
Stockholm University
SE-106 91 Stockholm
SWEDEN
Tel +46 8 164128
Fax + 46 8 156756

E-mail: jan@metabol.su.se

Expertise

Specialist in mitochondrial bioenergetics and influence of oxidative metabolism on energy balance and free radical generation. Special interest in uncoupling protein 1 (UCP-1) and the function, physiological significance, growth and differentiation of brown adipose tissue.

Relevant projects and functions

  • Dean, Biological Sciences, Stockholm University
  • Secretary, National Committee for Physiology, Pharmacology and Neuroscience, Sweden
  • Editorial advisory panel member, Biochemical Journal
  • Editorial advisory board member, Journal of Comparative Physiology
  • Editorial board member, Adipocytes

Group structure

1 Professor (M); 1 lecturer (M), 1 post-doc (F); 5 doctoral students (1M, 4F); 1 technician (F)

Selected publications

  1. Shabalina IG, Petrovic N, Kramarova TV, Hoeks J, Cannon B and Nedergaard J (2006); UCP1 and defense against oxidative stress: 4-Hydroxy-2-nonenal effects on brown-fat mitochondria are uncoupling protein-1 independent. J. Biol. Chem. 281, 13882-13893
  2. Shabalina IG, Jacobsson A, Cannon B, Nedergaard J (2004): Native UCP1 displays simple competitive kinetics between the regulators purine necleotides and fatty acids. J. Biol. Chem. 279, 38236-38248.