The association between obesity/diabetes and mitochondrial dynamics and oxidative phosphorylation

Background: Mitochondria are essential in aerobic metabolism and therefore of interest to the pathophysiology of diabetes. These organelles are highly dynamic (i.e. fission, fusion, autophagy), which is critical to maintain proper functioning. Implications in these processes have been linked to obesity and several diseases such as diabetes.

Questions: How does diet-induced obesity affect mitochondrial functioning? Which mitochondrial (dys)functions are associated with diabetes? Is mitochondrial dysfunction the cause or a consequence of diabetes?

Aim: Integrate results from research papers to create a literature overview that describes the association between diabetes and mitochondrial (dys)function.