Effects of environmental hypoxia on molecular adaptation of metabolism

Background: Oxygen is an essential nutrient. Sleep apnoea, obesity and aging can decrease oxygen availability for tissues in the body. This is thought to contribute to metabolic disease, but the mechanisms are still largely elusive.

Relevant questions: What is the role of limitation of oxygen availability in adipose tissue dysfunction? What is the role of limitation of oxygen availability in insulin resistance?

Aim: Define a specific research question related to one or more of the questions above. Write a logically structured report based on literature research question, focusing mechanisms involved. Conclude and propose an experiment that brings this research on step further.