Should we put cloths on mice for the study of energy metabolism?

Background:Environmental temperatures (Ta) affect thermoregulation in mammalian species including humans. Maintaining the body temperature (Tb) at a relative constant value requires energy. These energy requirements depend on Ta. The energy spend on thermoregulation also affects energy balance and thereby body weight regulation. With the major epidemic proportions of obesity and associated health problems many studies focus on the regulation of body weight, in order to find solutions to the health problems of obesity. Animal models are frequently used, but are mostly performed at standard Ta of around 22 ˚C.

Questions: What is the role of Ta on energy metabolism? Is this role the same in humans and in animal models for (disturbed) energy metabolism?

Aim: Integrate results from research papers to create a state-of-the art overview answering one or more questions related to this topic (the exact topic will be determined together with the supervisor).