The link between Sirtuin3 and energy metabolism

Background: Multiple organs and tissues comprise a very complex network in the regulation of metabolism throughout the body in mammals. This network is regulated by metabolic sensors such as SIRT3, which coordinate energy homeostasis in several tissues.

Questions: Which key factors and processes are influenced by SIRT3? What is the metabolic consequence of SIRT activation?

Aims: To make an overview of SIRT3 functioning in metabolism-related processes.