Publicaciones

NPLinker

Geng, Cunliang; Crocioni, Giulia; Rogers, Simon; Ramsay, Andrew; Duncan, Katherine; van der Hooft, J.J.J.; Hjörleifsson, Grímur; Soldatou, Sylvia; Huber, Florian; Wandy, Joe; Daly, Ronan; Louwen, J.J.R.; Medema, M.H.

Resúmen

NPLinker aims to address the significant bottleneck that exists in the realization of the potential of genome-led metabolite discovery, namely the slow manual matching of predicted biosynthetic gene clusters (BGCs) with metabolites produced during bacterial culture; linking phenotype to genotype.
NPLinker implements a new data-centric approach to alleviate this linking problem by searching for patterns of strain presence and absence between groups of similar spectra (molecular families; MF) and groups of similar BGCs (gene cluster families; GCF). Searches can be performed using a number of available analysis methods employed in isolation or together.