Research conducted by the Laboratory of Nematology is part of the research prgram of the Graduate School Experimental Plant Sciences (EPS) and the C.T. de Wit Graduate School for Production Ecology & Resource Conservation (PE&RC)
Research funded by Leniobio GmbH (Aachen, Germany), developer and manufacturer of ALiCE®.
The recent global pandemic caused by SARS-CoV-2 has revealed the susceptibility of humanity to new and/or re-emerging diseases. Despite of the global scientific endeavour in rapidly developing a safe and effective vaccine against SARS-Cov2, no fully approved vaccines are still available after almost one full year of the discovery of the virus. Henceforth, a niche exists for versatile vaccine and therapeutic production platforms capable of rapidly adapting to the ever-changing pathogenic threat.
Cell-Free Protein Synthesis (CFPS) systems could prove as promising candidate platforms for pandemic preparedness, given their open reaction conditions which allow for rapid adaptation to specific proteins. ALiCE® is an emerging eukaryotic CFPS platform that has shown potential compared to many other CFPS systems given its high yields, production of post-translational modifications and the possibility to scale-up reaction volumes. Given these characteristics, ALiCE® poses as one of the most promising CFPS systems to serve as a platform for pandemic preparedness.
In this project, the ALiCE® CFPS system will be explored to produce a variety of vaccine candidates alongside therapeutics. Special focus will be put into creating a versatile system capable of delivering rapid solutions to new or re-emerging diseases.