Secure animal health is of utmost importance for human health, animal welfare, resource efficiency and the effectiveness of livestock production. Food safety hazards, zoonotic diseases and the use of pharmaceuticals such as antibiotics have potential impacts on human health and wellbeing. Therefore, on-farm health and risk management is crucial to safeguard animal products as well as trade with livestock. Appropriate infrastructures for preventive health management to improve animal and human health and wellbeing are at the core of a 'one health' approach with provides a challenge at all levels of science and business. This chapter will inform you about: which structures have been established and which innovations have been made in riskoriented animal health and food safety management; how animal health management services and health status certification can be organised according to the AMOR principles; how and why on-farm biosecurity requirements have changed and how management support should be organised to foster a future one-health strategy.